Objective: To review the anti-psychiatric therapeutic interchanges drug therapy. Methods: It is an extensive search, or fifty databases comprised the following through the Saudi Digital Library (SDL) searching engine. It included the various types of studies (meta-analysis, randomized controlled studies and observational studies) in the English language with human study only for the update May 2017. The search in terms of therapeutic interchange, medication, therapy and type of disease or medication base on therapeutics class of anti-psychiatric. The medication list and switch from one drug to alternative based on the literature found the search that has included comparative safety, efficacy and cost of the type of medication for each disease and national or international evidence-based guidelines. Results: The total number of studies after an extensive search with a specific term search was 487 studies. Of those, there were 107 repeated studies, and 380 studies included for future assessment. After assessment, there were 20 studies discussed the therapeutic interchange of anti- Psychiatry. Of those 20 studies, three studies included for evaluation. Conclusion: Anti-psychiatric therapeutic interchange is seldom finding in the kinds of literature. Few observational studies discussed this matter. Further studies claim to standardized Anti-psychiatric therapeutic interchange in practice.