@article {119, title = {An Open Label, Randomized, Comparative Study of Antiscabietic Drugs Permethrin, Gamma Benzene Hexachloride and Ivermectin in Patients of Uncomplicated Scabies}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {3}, year = {2014}, month = {June 2014}, pages = {15-21}, type = {Research Article}, chapter = {15}, abstract = {

Background: To determine efficacy and cost effectiveness of antiscabietic drugs (permethrin, gamma benzene hexa-chloride and ivermectin) in patients of uncomplicated scabies. Materials and Methods: This was a prospective, randomized clinical study conducted in 210 diagnosed patients of scabies (\>12years of age) from January 2011 to October 2011.They were randomly allocated into one of the three groups. Group A received topical permethrin (5\% cream), Group B received topical gamma benzene hexachloride (1\% lotion) and Group C received oral ivermectin (tab 200mcg/kg). All the three groups received treatment two times- at the time of first visit and one week later. The patients were followed up at the end of first and third week. At each visit, cure rate was assessed by clinical and itching grading score and compared to determine the efficacy. Cost effectiveness was compared on basis of cost in INR to treat one case successfully. Results: Cure rate at the end of first week was 83.87\% in Group A, 78.18\% in Group B and 55.17\% in Group C while cure rate in the three treatment groups at the end of third week was 93.55\% in Group A, 80.00\% in Group B and 98.28\% in Group C. Thus at the end of first week Group A showed better cure rate while at the end of third week Group C was equally efficacious to Group A. The cost (INR) to treat one patient was 69.19 for permethrin, 37.50 for gamma benzene hexachloride and 24.42 for ivermectin. Conclusion: A single application of permethrin is superior to both ivermectin and gamma benzene hexachloride while ivermectin in two dose regimen is equally efficacious to permethrin and more cost effective than the other two conven-tional antiscabietic drugs. Oral ivermectin can be used as an alternative to permethrin.

}, keywords = {Antiscabietic, Gamma benzene hexachloride, Ivermectin, Permethrin}, author = {Maurya Meenakshi and Kaushik Sadhna and Srivastava Neeraj and Verma Deepak and Parihar Renu} }