@article {125,
	title = {Chelation of Lanthanum (La3+) by Various Thiols - an in vitro Study},
	journal = {International Journal of Pharmacology and Clinical Sciences},
	volume = {3},
	year = {2014},
	month = {June 2014},
	pages = {34-38},
	type = {Short Communication},
	chapter = {34},
	abstract = {<p class="rtejustify">In the present study the interaction of various thiols (L-glutathione, L-cysteine, N-acetyl cysteine and D-penicillamine) with LaCl<sub>3</sub> was studied in vitro by modified Ellman{\textquoteright}s method. Experiments carried out at various concentrations inferred gradual decrease in thiol concentration with the increase in La<sup>3+</sup> concentration in aqueous solutions. Maximum interac-tion between thiols and La<sup>3+</sup> was observed at pH 7.5 and 35{\textdegree}C as indicated by the lowest values of residual thiol con-centration. The order of reactivity was DPA\&gt;GSH\&gt;NAC\&gt;Cys, where reactivity increased with increasing <em>pKa</em> of their thiol group. The possible products of reaction are proposed to be La(RS)<sub>3</sub> complex or oxidized form with disulfide bond (RSSR).</p>
},
	keywords = {Chelation, Ellman{\textquoteright}s modified method, Lanthanum, Thiols},
	author = {Muhammad Yaqoob and Muhammad Farid Khan and Muhammad Tausif Chaudhry and Izhar Ahmad Shaikh}
}
