@article {132, title = {Anti-ulcer Activity of Herbo-mineral Formulation (Asecure capsule) Against Experimentally Induced Acute and Chronic Gastric Ulcers in Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {3}, year = {2014}, month = {September 2014}, pages = {61-67}, type = {Research Article}, chapter = {61}, abstract = {

Background: This study was aimed to investigate anti-ulcer activity of a herbo-mineral formulation (Asecure capsule) in ethanol-induced acute gastric ulcer and acetic acid-induced chronic gastric ulcer. Materials and Methods: Absolute methanol (5 mL/kg, p.o.) was administered for development of acute gastric ulcer. In another model, 50\% acetic acid was exposed to serosal surface of stomach to produce chronic gastric ulcer. For each experiment, animals were divided in to three groups where each group was consisting of six animals. Group-I, II and III were considered as Normal control, Disease control and test drug treated respectively. Herbo-mineral formula-tion (Asecure Capsule) was administered at 100 mg/kg/day, orally. Ulcer index, gastric wall mucus content, lipid perox-idation level in stomach tissue and tissue anti-oxidant parameters like superoxide dismutase, reduced glutathione and catalase enzyme activity were carried out for both experimental studies. Histopathology of stomach tissue was also performed. Statistical calculations were done by analysis of variance (ANOVA) followed by post hoc Bonferroni{\textquoteright}s test. Results: Induction of ethanol and acetic acid caused significant alteration in ulcer index, gastric wall mucus content and lipid peroxidation level in comparison to normal control group whereas treatment of Asecure capsule showed sig-nificant cyto-protection and recovery against ethanol and acetic acid induced acute and chronic ulcer respectively. Treatment with Asecure capsule) also showed significant increase in level of antioxidant enzymes in comparison of disease control groups. Histopathology of stomach showed remarkable cyto-protection. Conclusion: On the basis of present data it can be concluded that Asecure capsule) possesses significant anti-ulcer activity against exposure to a noxious agent like ethanol and acetic acid. The observed effect be due to synergistic anti-oxidant property of ingredients of the herbo-mineral formulation.

}, keywords = {Anti-ulcer activity, Ethanol and acetic acid induced gastric ulcer, Herbo-mineral}, author = {Hardik Soni and Ankur Shah and Arindam Paul and Ghanshyam Patel} } @article {155, title = {Evaluation of Anti-arthritic Activity of Dazzle Ointment - A Polyherbal Formulation}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {2}, year = {2013}, month = {March 2013}, pages = {14-18}, type = {Research Article}, chapter = {14}, abstract = {

Background: Rheumatoid arthritis is a chronic multi-system disease of unknown cause. It affects people in their prime of life, predominantly between the ages of 20-50 years with unpredictable course. Dazzle ointment is a polyherbal for-mulation, used for the treatment of inflammation and rheumatoid arthritis. Objective: The present study was planned to evaluate efficacy of Dazzle ointment using complete Freund{\textquoteright}s adjuvant-induced arthritic model. Materials and Methods: The animals were divided into three groups of 6 animals each as CFA treated, standard drug and test drug treated groups. The animals were injected with 0.2 ml of complete Freund{\textquoteright}s adjuvant into the sub-plantar surface of left hind paw. Drugs were administered topically, once a day, commenced on the day of injection of adjuvant and continued for 21 days. The assessment of the change in the inflammatory reaction was made by measuring the paw volume plethysmographically on 0, 4th, 14th, 17th, 21st day after injection of complete Freund{\textquoteright}s adjuvant (CFA). The statistical significance was assessed using one-way analysis of variance (ANOVA) followed by Dunnet{\textquoteright}s compari-son test. A p value of \< 0.05 was considered as statistically significant. Results: It was observed that Dazzle ointment produced significant anti-arthritic effect on 21st day. In CFA treated group, there was marked increase in the ESR and WBC count which was significantly decreased by test drug Dazzle ointment and standard drug diclofenac gel (Omni gel). Conclusion: The results indicate that Dazzle ointment possesses anti-arthritic activity in the experimental animal model.

}, keywords = {Anti-arthritic, Complete Freund{\textquoteright}s adjuvant, Dazzle ointment, Plethysmometer}, author = {Hardik Soni and Ghanshyam Patel and Megha Shah and Mayank Panchal and Krishna Murti} }