@article {52, title = {Pharmacist{\textquoteright}s Awareness and Knowledge of Reporting Adverse Drug Reactions in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {8}, year = {2019}, month = {January 2019}, pages = {60-65}, type = {Research Article}, chapter = {60}, abstract = {

Objectives: Pharmacovigilance is considered a useful tool in detecting, assessing, understanding and preventing Adverse drug reactions (ADRs) to ensure the safety of medications and protect consumers from ADRs. Consequently, the progression and expansion of pharmacovigilance is urgent for safe and effective clinical practice; therefore, in this study, we aimed to compare the awareness and knowledge of the community and hospital pharmacists toward reporting ADRs in different regions of Saudi Arabia. Methods: This cross-sectional study was conducted from January 2016 to March 2016 in Saudi Arabia. A validated and structured questionnaire was distributed by hand or via Internet to 263 hospital and community pharmacists. The questionnaire collected pharmacists{\textquoteright} demographic information and pharmacists{\textquoteright} understanding and knowledge of the pharmacovigilance system and reporting of ADRs. Results: A total of 263 pharmacists responded to the questionnaire with 208 (79.09\%) pharmacists from hospital pharmacy sites and 55 (20.91\%) pharmacists from community pharmacy responding to the questionnaire. There is a significant difference in the pharmacovigilance concept (p\<0.05) between the hospital and community pharmacists. Most community pharmacists were unfamiliar with the existence of a pharmacovigilance center in Saudi Arabia. Furthermore, community pharmacists were unaware of where they could get an ADR reporting form, but hospital pharmacists were aware of this (p\<0.05). Conclusion: The results of this study demonstrated that pharmacists who work at hospitals among different regions in Saudi Arabia had a higher awareness of the pharmacovigilance system than that of community pharmacists who worked at the community pharmacy.

}, keywords = {Adverse drug reactions, Awareness, Knowledge, Pharmacists, Pharmacovigilance, Saudi Arabia}, doi = {10.5530/ijpcs.2019.8.11}, author = {Fatimah Fouad Al Doughan and Yousef Ahmed Alomi and Mais Hasan Iflaifel} } @article {55, title = {Pharmacist{\textquoteright}s Perception of Pharmacovigilance and Reporting of Adverse Drug Reactions in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {8}, year = {2019}, month = {February 2019}, pages = {73-78}, type = {Original Article}, chapter = {73}, abstract = {

Background: Pharmacists{\textquoteright} perception toward their role in reporting of Adverse Drug Reactions (ADRs) and their understanding of the importance of reporting ADRs are essential keys to be assessed and studied in order to determine the factors that may predispose to underreporting of ADRs in Saudi Arabia. Therefore, in this study, we aimed to asses and compare the perception of community and hospital pharmacists toward reporting of ADRs in different regions of Saudi Arabia. Method: A structured, validated questionnaire was used to conduct a cross-sectional study. A total of 263 pharmacists were enrolled. The questionnaire included the demographic data of the pharmacists and 11 questions to measure pharmacists{\textquoteright} perceptions of ADRs reporting of reporting ADRs. All statistical analysis done by using Statistical Package for the Social Sciences (SPSS) version 21 and Survey Monkey system. Result: the result shows that community and hospital pharmacists strongly agree about that reporting of ADRs allow to measure the incidence of ADRs 29 (55.77\%), 121 (58.45) and to identify previously unrecognized ADRs 30 (57.69\%), 116 (56.59\%) and enable safe drugs to be identified 39 (70.91\%), 129 (62.32\%), respectively with no significant difference (p\>0.05). Besides, both hospital pharmacists 116 (55.77\%) and community pharmacists 31 (60.78\%) strongly agree about their important role in the pharmacovigilance system. However, only 67 (32.52\%) of hospital pharmacists strongly agreed about the physician{\textquoteright}s responsibility in reporting ADRs compared to community pharmacists 29 (52.73\%) with a significant difference between groups (p\<0.05). However, 37 (17.87\%) of hospital pharmacists were uncertain about drug companies{\textquoteright} role in pharmacovigilance system with a significant difference between community pharmacists with (p\<0.05). Conclusion: The result of this study demonstrated that both community and hospital pharmacists among Saudi Arabia had a very goods of perception about the importance of ADRs reporting and their role in reporting ADRs.

}, keywords = {Adverse drug reactions, Community, Hospital, Perception, Pharmacist, Pharmacovigilance, Saudi Arabia}, doi = {10.5530/ijpcs.2019.8.13}, author = {Fatima Fouad Al Doughan and Yousef Ahmed Alomi and Mais Hasan Iflaifel} } @article {56, title = {Pharmacist{\textquoteright}s Practice of Reporting of Adverse Drug Reactions in Saudi Arabia}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {8}, year = {2019}, month = {February 2019}, pages = {86-93}, type = {Research Article}, chapter = {86}, abstract = {

Objectives: To assess and compare the practice of reporting Adverse Drug Reactions (ADRs) and related factors between community and hospital pharmacists in Saudi Arabia. Methods: This is a cross-sectional study. We used a structured, validated questionnaire to collect the data. A total of 263 pharmacists participated in the survey. The questionnaire captures demographic data of the participants and had 26 questions related to the practice of reporting ADRs and factors that encourage and discourage pharmacists from reporting ADRs. Results: Community pharmacists did not know the location of the ADR form, but hospital pharmacists did know about it, which was significantly different (P\<0.05). Despite the increased awareness of ADR form among the hospital pharmacists{\textquoteright}, the overall reporting rate was found to be meager among both the group of pharmacists. We found that several reasons led to the low reporting rate of ADR, for example, community pharmacists were unaware of how to report ADR and they considered that the ADR is too trivial to be reported compared to hospital pharmacists (P\<0.05). in addition, community pharmacists were not know whom to report the ADRs compared to the hospital pharmacists, which was significantly different (P\<0.05). Conclusion: The results of this study demonstrated that pharmacists who work at hospitals had a higher awareness of practicing system of reporting ADRs than that of community pharmacists. Increasing awareness among community pharmacists regarding the pharmacovigilance and ADR reporting systems is highly recommended in the Kingdom of Saudi Arabia.

}, keywords = {Adverse drug reactions, Community, Hospital, Pharmacist, Pharmacovigilance, Practice, Saudi Arabia}, doi = {10.5530/ijpcs.2019.8.15}, author = {Fatima Fouad Al Doughan and Yousef Ahmed Alomi and Mais Hasan Iflaifel} } @article {101, title = {A Study of Adverse Drug Reactions in Patients Treated with Penicillins in a Rural Tertiary Care Hospital}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {5}, year = {2016}, month = {June 2016}, pages = {41-44}, type = {Research Article}, chapter = {41}, abstract = {

Background: Adverse drug reactions (ADR) are rated as the fifth leading cause of death among all diseases. Approximately 5-8\% of all hospitalization worldwide is due to ADR. Objectives: The present study was conducted with the aim of analyzing the pattern of Adverse Drug Reactions occurring from penicillins, their manifestations and severity. Methods: A non interventional observational prospective study was conducted over 2 years from Jan 2014 to Dec 2015 in KIMS Narketpally. The red boxes for dropping the filled yellow adverse drug reactions forms were installed in all the wards and outpatient departments. Additional information and missing data was obtained personally by either consulting the physician or through case sheets. Results: The most common penicillin implicated in causation of adverse drug reactions was combination of amoxicillin and clavulanic acid (54\%), followed by Piperacillin (21\%). Most of the reactions were of moderate severity. The most commonly observed adverse drug reactions were dermatological reactions (37\%). Majority of the adverse drug reactions belonged to probable category (71\%) according to WHO scale. Conclusion: Dermatological reactions are the most common adverse drug reactions occurring due to penicillin and combination of amoxicillin and clavulanic acid was the most common causative penicillin. The health care providers should make an attempt for early detections of ADRs and be vigilant about safety profile monitoring of the prescribed medicines. This will not only decrease the morbidity and mortality but also the health care cost.

}, keywords = {Adverse drug reactions, Amoxicillin, Penicillin, Pharmacovigilance}, doi = {10.5530/ijpcs.5.2.1}, author = {Shivaraj Basavaraj Patil and Shrinivas R Raikar and Bhaskar HN and M Janardhan and Y Venkata Rao and Vahila} } @article {133, title = {A Review on Drug-Drug and Drug-Food Interactions in Patients During the Treatment of Diabetes Mellitus}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {4}, year = {2015}, month = {Dec 2015}, pages = {98-105}, type = {Review articles}, chapter = {98}, abstract = {

Drug interaction is defined as the modification of the effects of a drug (object drug) by the prior and/or the concomitant administration of another drug (precipitant drug). Drug interaction may either increase or decrease the intended effect of one or both drugs. It may transform the diagnostic, preventive or therapeutic activity of any drug. Drug-interactions can be an extremely main contributory factor for the incidence and occurrence of adverse drug reactions and adverse drug events. The rate of occurrence and incidence of drug interactions is much higher in patients receiving combinations of drugs or poly-pharmacy or suffered from co-morbidity of diseases such as diabetes, hypertension, peptic ulcer, fungal infections and neurodegenerative disorders, which require prolong and multi treatments and the risk of drug interaction will increase as they are treated with multi-therapies. It is concluded that diabetic patients are at higher risk for drug interaction as receiving a combination of therapies for diabetic complications as well, so that the rate of occurrence of drug interaction is rapidly amplifying. Diabetes mellitus has been considered as a foremost public health challenge around the world because of its high prevalence and associated increase in morbidity and mortality. The main objective of this review study is to highlights the various drug interactions likely drug-drug and drug-food interactions as well as reports unwanted effects of other treatment associated with antidiabetic agents in the diabetic patients.

}, keywords = {Adverse drug reactions, Diabetes Mellitus, Drug Interaction, Drug-drug Interaction, Drug-food Interaction, Polypharmacy}, doi = {10.5530/ijpcs.4.4.6}, author = {Sonu and Gopal Sharma and SL. Harikumar and Silvia Navis} } @article {94, title = {A Study on Adverse Drug Reactions to first line Antitubercular Drugs in DOTS Therapy}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {4}, year = {2015}, month = {March 2015}, pages = {7-11}, type = {Research Article}, chapter = {7}, abstract = {

Background: Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis, is the second leading infectious cause of death in the world. The objective was to study the demographic details of the tuberculosis patients experiencing adverse drug reactions (ADRs) and to identify the frequency of adverse drug reactions. Materials and Methods: : It was a prospective observational study conducted in pulmonology department of Institute of Chest Disease, Govt. Medical College, Kozhikode, Kerala, India. All the TB patients admitted at the directly observed treatment, short course (DOTS) Center at Medical College Hospital were enrolled and were monitored for ADRs. The causality and severity of the reactions were determined using Naranjo algorithm and Hartwig question-naire, respectively. Results: A total of 511 tuberculosis patients who were on DOTS therapy were enrolled for the study. Out of 511 pa-tients, 93 patients (18.20\%) developed adverse drug reactions. The higher numbers of ADRs were observed in males (68.81\%) and the remaining (31.18\%) was observed in female. Diabetes mellitus (41.02\%) was the most common comorbidity. Most of the ADR occurred in the intensive phase (85.71\%) of treatment. It was observed that pulmonary TB (55.18\%) was more common than extra pulmonary TB. Majority of adverse drug reactions were gastrointestinal (GI) problems (38.09\%). The most serious ADR was hepatitis. Isoniazid was the major drug which caused 34.40\% of adverse drug reactions. Conclusion: About 17.02\% people developed different type of ADRs during the study period. As a pharmacist we have the liability to support the patients during the period of antitubercular treatment. These ADR may steer the patient to make a judgment for stopping the medications and finally the occurrence of drug resistance and an amplified healthcare cost. If a proper educational system is implemented, most of the patients may report their ADR and thereby we can improve the patient adherence and therapeutic outcome.

}, keywords = {Adverse drug reactions, Ethambutol, Isoniazid, Pyrazinamide, Rifampicin, Tuberculosis}, author = {Athira B and Manju CS and Jyothi E} } @article {187, title = {Knowledge and Awareness of Food and Drug Interactions (FDI): a Survey Among Health Care Professionals}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {1}, year = {2012}, month = {Dec 2012}, pages = {105}, type = {Research Article}, chapter = {97}, abstract = {

Background:\ Most of the food and drug interactions (FDI) remain unnoticed and under reported due to either lack of proper history, follow up or unawareness. Certain foods and specific nutrients in foods, may affect the overall bioa-vailability, pharmacokinetics, pharmacodynamics and therapeutic efficacy of medications. FDI occur due to extension of drug action or due to interaction between the drug and herbal medicines as well as dietary supplements and food products.\ Objectives:\ To evaluate the knowledge, attitude and awareness regarding the common FDI among the doctors in their day to day practice.\ Materials and Methods:\ Survey included randomly selected 200 doctors divided into 3 groups [65 Professors, 83 Post Graduates (PGs) and 52 Interns] from JSS Tertiary care hospital, Mysore, India. Assessment was through FDI Questionnaire which consisted of 32 questions (included dichotomous, multiple choice and open ended ques-tions). The differences between groups were compared using one-way ANOVA followed by Bonferroni{\textquoteright}s post-hoc test. The level of significance was set at p \< 0.05.\ Results:\ The mean scores (mean {\textpm} SD) on the overall test were 26 {\textpm} 4.08, 22.89 {\textpm} 3.72, 21.35 {\textpm} 4.2 for professors, PGs and interns respectively, with 31 being a perfect score. Professors had good knowledge about FDI compared to others (p \< 0.001). Only 33\% participants have noticed FDI during their practice. A majority of doctors had heard, felt necessary to report and update their knowledge about FDI along with adequate patient counseling.\ Conclusion:\ The study showed professors had better expertise compared to others. Intensive FDI training and integration of knowledge among healthcare professionals, especially in the younger health care professionals, is a requisite.

}, keywords = {Adverse drug reactions, Drug interactions, Food and Drug Interactions, Questionnaire}, author = {Jyoti M. Benni and Jayanthi MK and Basavaraj R and Tubaki and Renuka M} }