02510nas a2200229 4500008004100000245013500041210006900176260001500245300000800260490000600268520178800274653002002062653001902082653002802101653003102129100001902160700002002179700001702199700002002216700000502236856003902241 2014 eng d00aComparative Evaluation of Antimicrobial and Anticonvulsant Induced Cases of Steven Johnson Syndrome and Toxic Epidermal Necrolysis0 aComparative Evaluation of Antimicrobial and Anticonvulsant Induc cMarch 2014 a1-60 v33 a

Background: Steven Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) constitute a spectrum of severe, potentially life threatening, mucocutaneous adverse drug reactions. Antimicrobial agents and anticonvulsants are the most commonly implicated drugs. This study was aimed to compare and analyse the differences in the incubation peri-od, clinical presentation and outcome in patients of SJS/TEN caused by the antimicrobials and anticonvulsants. Materials and Methods: Patients of SJS, TEN and SJS/TEN overlap admitted in the dermatology ward of our hospi-tal, in whom an antimicrobial agent or an anticonvulsant were found to be probable causative agent by Naranjo score were assigned to Group A and B respectively. Inpatient records of the selected patients were studied to compare the differences. Results: Total of forty patients (twenty each of Group A and B) were included in the study. Fluoroquinolones followed by chloroquine were the most commonly implicated antimicrobials. The anticonvulsants most commonly implicated were phenytoin followed by carbamazepine. Incubation period in the antimicrobial group was significantly shorter [Group A (7.32 ± 5.4 days) vs Group B (28.58 ± 19.35 days)] with p value < 0.001. The duration of stay, in the derma-tology ward, was significantly longer (p value< 0.05) in the cases of TEN caused by antimicrobials (20.1 ± 7.49 days) as compared to those caused by anticonvulsants (14.5 ± 5.36 days). Three patients in Group A and one patient in Group B expired. Conclusion: A shorter incubation period and a higher morbidity and mortality were seen in the antimicrobial induced cases as compared to the anticonvulsant group.

10aAnticonvulsants10aAntimicrobials10aSteven Johnson syndrome10aToxic epidermal necrolysis1 aDayal, Surabhi1 aMonga, Brahmita1 aJain, V., K.1 aAggarwal, Kamal1 a uhttps://ijphs.org/article/2014/3/1