01972nas a2200217 4500008004100000245017100041210006900212260001400281300001000295490001900305520122300324653002601547653001901573653001601592653001601608100002301624700002001647700001601667700001701683856005401700 2016 eng d00aMuscle Relaxant Property of 1(4-carboxy phenyl)-4,4,6-trimethyl-1H, 4H pyrimidine-2 thiol (a Pyrimidine Derivative) in Ex vivo Smooth and Skeletal Muscle Preparations0 aMuscle Relaxant Property of 14carboxy phenyl446trimethyl1H 4H py cJune 2016 a49-540 v5 3 a

Background: Pyrimidine and its derivatives demonstrate a wide range of biological and pharmacological activities. Objective: To study the smooth muscle and skeletal muscle relaxant activity of a pyrimidine derivative 1 (4-carboxy phenyl)-4,4,6-trimethyl-1H,4H pyrimidine- 2 thiol (4CPTP), the chemical structure of which is similar to phenobarbitone. Material and Methods: Spasmolytic activity of 4CPTP was studied using rabbit ileum and guinea pig ileum preparation. Skeletal muscle relaxant activity was assessed on frog rectus abdominis preparation. Mean height of contractions with graded doses of phenobarbitone and 4CPTP along with mean inhibition of contractions were calculated. Statistical analysis was done using chi square test. Results: The test compound produced dose dependent decrease in acetylcholine and barium chloride induced contractions of rabbit ileum, histamine induced contractions of guinea pig intestine and acetyl choline induced contractions of frog rectus abdominis. Conclusion: 4 CPTP possesses spasmolytic and neuromuscular blocking activity in our ex vivo studies.

10aNeuromuscular blocker10aPhenobarbitone10aPyrimidines10aSpasmolytic1 aVerma, Prem, Kumar1 aBhutani, Garima1 aRani, Seema1 aSaini, Rahul uhttps://ijphs.org/article/2016/5/2/105530ijpcs523