AbstractAbstractInternational Journal of Pharmacology and Clinical Sciences,2015,4,4,76-82.DOI:10.5530/ijpcs.4.4.2Published:Dec 2015Type:Research ArticleAuthors:Vandana Shamrao Nade, Pranita Pradip Dharmadhikari, and Laxman Ashok Kawale Author(s) affiliations:Vandana Shamrao Nade*, Pranita Pradip Dharmadhikari, Laxman Ashok Kawale Department of Pharmacology, M.V.P. Samaj’s College of Pharmacy, Gangapur Road, Nashik, Maharashtra-422002, INDIA. Abstract:Background: Angiotensin receptor blockers are the new class of compounds used for the treatment of fibrotic diseases. Objectives: The purpose of this study was to investigate cardioprotective effect of irbesartan in isoproterenol induced endoplasmic reticulum stress, which results in myocardial fibrosis. Materials and Methods: Thirty wistar rats were assigned to study, 6 rats in a group. Myocardial fibrosis was induced by isoproterenol (5 mg/kg, s.c. for 15 days) which can cause cardiac toxicity. Irbesartan (10, 20 and 30 mg/kg, p.o.) was administered for 15 days after administration of isoproterenol. Post-treatment with irbesartan, cardiac functional measurements and the left and right ventricular weight indices were analyzed. Pathological alteration of levels of soluble collagen was determined. Results: The administration of irbesartan resulted in a significant (p<0.01) improvement in cardiac function and reduced levels of soluble collagen. Irbesartan also showed decrease in the level of malondialdehyde and an increase in defensive antioxidant enzymes (SOD, CAT, and GSH) thus, exerts antioxidant activity. Conclusion: Irbesartan possesses anti-fibrotic activity and offers protection against myocardial fibrosis, due to regulation of angiotensin II activity through blockade of AT1 receptors which might attenuate the endoplasmic reticulum stress and thus inhibit myocardial fibrosis via inhibition of oxidative stress. The regulation of antioxidant defensive enzymes may be involved in anti-fibrotic effect of irbesartan Keywords:Endoplasmic Reticulum Stress, Irbesartan, Isoproterenol, Myocardial Fibrosis, Oxidative Stress, Soluble CollagenView:PDF (406.96 KB) PDFClick here to download the PDF file. Images The concentration dependence of the absorbance of collagen solution of control group in ringer solution at 650 nm (Hydroxyproline assay) emailfacebooklinkedintwittergoogle+pinterest ‹ Prophylactic and Curative Activity of 'Barleria Buxifolia. Linn' on Experimentally Induced calcium Oxalate Nephrolithiasis in Animal Model up Towards Standardization–A New Protocol for Oil drop test (Neikuri) in Healthy Subjects ›