International Journal of Pharmacology and Clinical Sciences, 2012, 1, 3, 79-81.
Published: September 2012
Type: Short Communication
Authors: R. Sathish, R. Madhavan, Hannah R. Vasanthi, and Arul Amuthan
Author(s) affiliations:
R. Sathish1, R. Madhavan2, Hannah R. Vasanthi3, Arul Amuthan4*
1Department of Toxicology, Sri Sairam Siddha Medical College, Chennai, India
2Department of Toxicology, National Institute of Siddha, Chennai, India
3Herbal and Indian Medicine Research Laboratory, Department of Biochemistry, Sri Ramachandra University, India
4Department of Pharmacology, Melaka Manipal Medical College, Manipal University, India
Abstract
The present study was carried out to evaluate alpha-glucosidase inhibitory activity of abraga chendhooram, which is a Siddha drug being used to treat diabetes mellitus. The ingredient of abraga chendhooram includes biotite (K(Mg,Fe)3AlSi3O10(F,OH)2), Sesbania grandiflora, Calotropis gigantea, and Momordica charantia. In-vitro alpha-glucosidase inhibitory assay was performed by standard procedure. Different concentrations of abraga chendhooram and miglitol (standard drug) were used. Abraga chendhooram exhibited a dose-dependent alpha-glucosidase inhibitory activity, but it was less than the standard drug. Further studies are warranted to look at other possible mechanisms for its antidiabetic claim and to assess its safety.