Objectives: The present study aimed to affirm the dentist’s knowledge of medication safety in the Kingdom of Saudi Arabia. Methods: It is an analysis of a cross-sectional survey that conferred dentists’ knowledge of medication safety in Saudi Arabia. Selfreported an electronic survey of dentists, comprising dentists from internship to the consultant, dental specialisms in Saudi Arabia. The survey contained respondents’ demographic information about dentists and knowledge information of designated medication safety elements, and the resources of knowledge of medication safety elements in dental care. The 5-point Likert response scale system was employed with closed-ended questions. The data analysis of the dentist’s knowledge of medication safety is completed through the survey monkey system. The statistical package of social sciences (SPSS), Jeffery’s Amazing Statistics Program (JASP), and Microsoft excel sheet (version 16) were used in the study. Results: The total number of responding dentists was 242, with the mainstream of them coming from the central region 95 (39.26%) with statistically substantial among the areas (p<0.05). Of those, 144 (59.75%) were male, while 97 (40.25%) were female, with statistically significant between them (p<0.05). The total average scores of dentist knowledge of medication safety in dental care were 2.78 with high scores element, knowledge of the high alert medication in dental care was 3.48, consider the Medication Errors (MEs) as a sentinel event (3.25), and familiar with medications reconciliation in dental care (3.23). The most resources employed for medication safety for dental care were health practitioners [129 (54.20%)] and scientific literature [118 (49.58%)]. The reliability test was evaluated in McDonald’s ω (0.955) and Cronbach alpha (0.955). Conclusion: The dentist’s knowledge of medication safety was insufficient in the kingdom of Saudi Arabia. Targeting training and education of dental medication safety during undergraduate and postgraduates school of dentistry is highly suggested to improve patient’s safety in dental care in Saudi Arabia.