Objectives: The study aims to discover the dentist’s perceptions of medication safety in the Kingdom of Saudi Arabia. Methods: It is an analysis of a cross-sectional survey that reconnoitered the dentist’s medication safety perceptions in Saudi Arabia. It selfreported an electronic survey of dentists, comprising dentists from internship to the consultant, dental specialties in Saudi Arabia. The survey contained respondents’ demographic information about dentists and perception of medication safety in dental care. Also, the perception of barriers averts off employment of the medication safety system in dental care. The 5-point Likert response scale system was employed with closed-ended questions. The data analysis of the dentist’s knowledge of medication safety is finished through the survey monkey system. The statistical package of social sciences (SPSS), Jeffery’s Amazing Statistics Program (JASP), and Microsoft excel sheet version 16 were used in the study. Results: The total number of responding dentists was 242, with the majority of them coming from the central region 95 (39.26%) with statistically momentous among the areas (p<0.05). Of those, 144 (59.75%) were male, while 97 (40.25%) were female, with statistically significant between them (p<0.05). The average scores of dentist’s perceptions of medication safety in dental care were 3.99; the dentist’s high scores component was relaxed to ask for assistance support from colleagues or peers concerning medication safety (4.27). Medications storage with labeling is a vital element of medication safety in dental care (4.26). The average scores of perception of barriers prevent you from instigating medication safety in dental care (3.52). The high scores element was level of clinical knowledge about dental medications safety services (3.98) and lack of periodic training of dental staff dental medications safety services (3.94). The reliability test includes Cronbach alpha (0.933) and McDonald’s ω (0.920). Conclusion: The dentist’s perceptions of medication safety were flawless in Saudi Arabia. Periodic education and training medication safety in dental care is obligatory to improve the dental medication safety system and patient outcomes in dental care in Saudi Arabia.