@article {162, title = {Evaluation of Gastroprotective Role of Alpha-tocopherol in Indomethacin Induced Peptic Ulcer in Albino Rats}, journal = {nternational Journal of Pharmacology and Clinical Sciences}, volume = {1}, year = {2012}, month = {June 2012}, pages = {39-44}, type = {Research Article}, chapter = {39}, abstract = {

Background:\ Oxidative free radicals induce gastric injury in animal models of peptic ulcer. Hence antioxidants may provide gastroprotection.\ Objectives:\ The present study was undertaken to evaluate the gastroprotective role of antioxidant alpha-tocopherol in indomethacin induced gastric ulceration in albino rats.\ Materials and methods:\ Animals were diveded into 3 groups (n=6) group 1 (control which received distilled water), group11 (alpha-tocopherol 12.5 mg/kg) and group 111 ( omeprazole 3.6 mg/kg). Each group received the corresponding 4 hours, animals were sacrificed and their stomachs were studied for ulcerationm, adherent mucin content, and ulcer index was calculated. The results of alpha-tocopherol were compared with those of control and omeprazole treated groups and data was analyzed manually using Student t test. A p Value of \< 0.05 was considered as satistically significant.\ Results:\ Alpha-tocopherol administrative reduce ulceration and ulcer index compared to control group (t cal5.2\>tab 2.23 at 5\% level of significance, p\<0.05). Omeprazole treatment also reduced ulcer index and ulceration in comparison to control group (tcal 6.2\>ttab 3.16 at 1\% level of significance, p\<0.01). Thus results of test drug were similar to omeprazole treated group.\ Conclusion:\ Alpha-tocopherol treatment provides gastroprotection in indomethacin induced gastric ulceration.

}, keywords = {Alpha-tocopherol, Antioxidant, Gastroprotection, Indomethacin}, author = {Shobha V Huligol and V. Hemanth kumar and K. Narendar} }