@article {159, title = {Hepatoprotective Activity of Plectranthus Amnoinicus Against Paracetamol Induced Hepatotoxicity in Rats}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {1}, year = {2012}, month = {June 2012}, pages = {32-38}, type = {Research Article}, chapter = {32}, abstract = {

Background:Plectranthus amboinicus, belonging to the genus Plectranthus, is widely used for medicinal purposes. Its leaves have been used traditionally as a heatoprotective.\ Objectives:\ The present study was aimed at evaluating the heapatotective activity of ethanolic extract of Plectranthus amboinicus against paracetamol induced heapatotoxicity in rats.\ Materials and Methos:\ Sic groups wistar rats were used in the study. The two control groups received gum acacia and paracetamol orally respectively. The three test groups were treated orally with paracetamol followed by 300, 600 and 900 mg/kg of ethanolic extract of pletranthus amboinicus respectively. The sixth group (standard hepatoprotective) received paracetamol followed by N-aceltylcysteine 100 mg/kg orally. The hepatoprotective activity was evaluated by estimating serum alanine aminotransferase, asparatate aminotransferase, alkaline phosphatase, tissue malondialdehyde levels and by histopathological analysis of the liver tissue. Results were analysed by one-way ANOVA followed by Dunnett{\textquoteright}s multiple comparison test.\ Results:\ Plectranthus amboinicus in doses of 600 mg/kg and 900 mg/kg siginificantly (p\<0.05) altered paracetamol induced changes in the serum and tissue enzyme levels to near normal values. It also improved the liver histopathology profile.\ Conclusion:\ The results of the study indicate that the ethanolic extract of Plectranthus amboinicus, possesses hepathoprotective activity against paracetamol induced hepatotoxicity in rats.

}, keywords = {Hepatoprotective, N-acetylcysteine, Paracetamol, Plectranthus Amboinicus}, author = {Smita Shenoy and Hemanth Kumar and Thashma and Veena Nayak and Krishnananda Prabhu and Priya Pai and Indu Warrier and Somayaji and Venu Madhav and KL Bairy and Anoop Kishore} } @article {171, title = {Undergraduate Medical Srtudent{\textquoteright}s Perceptions Regarding Personal Drug Selection Exercise}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {1}, year = {2012}, month = {June 2012}, pages = {61-67}, type = {Research Article}, chapter = {61}, abstract = {

Background:\ Right drug for the right patient in the right dose for the right duration is the aim of rational prescribing. The foundation for rational prescribing can be laid if prescribing doctors are sensitized to this concept during undergraduate studies. The knowledge of personal drug (P-drug) selection process is an important step towards rational prescribing.\ Objectives:\ This study was done to analyse tje student{\textquoteright}s opinions and the difficulties they faced in the process of P-drug selection. Materials and Methods: In first phase of this study, fifth sesmester students of MBBS course were taught the process of selecting a P-drug in pharmacology practical classes. In seconf phase. students were given questionnaire to put forth their views on selection process of P-drug. The qunatitative data was expressed as median and interquartile range (IQR).\ Results:\ Majority of the students were in favor of introducing the process of selection of P-drug in udergraduate pharmacology curriculum [4 (4-5), scale 1-5]. The students were of the opinion that such exercise will given in-depth knowledge of various groups used and highlight the intragroup differences. Student{\textquoteright}s also opined that P-drug knowledge of various groups of durgs used and highlight the intragroup differences. Student{\textquoteright}s also opined that P-drug exercise also enable them to remember various aspects of the drugs for long period. Students also felt that the P-drug selection process will help them to understand hoe drug selection been for the treatment of various disease conditions.\ Conculsion:\ P-drug selection exercise helps students to understand the differences between various drugs used for the treatment of one disease condition. This may serve as a strong foundation for developing rational prescribing skills.

}, keywords = {P-drug, Pharmacology, Prescription Writing, Undergraduate Curriculum}, author = {Lalit Mohan and Bharti Chogtu and Shalini Adiga and K.L Bairy and Anoop Kishore} }