@article {87, title = {Prevalence and Severity of Adverse Drug Reactions (ADRs) in Patients Subjected to Different Anti-psychotic Drugs in an Out-Patient Department of a Psychiatry Hospital in Kashmir; A Prospective Observational Study}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {5}, year = {2016}, month = {March 2016}, pages = {12-16}, type = {Research Article}, chapter = {12}, abstract = {

Background: Adverse effects are usually dose dependent and can be influenced by patient characteristics including age and gender and these confounding factors should be considered in clinical practice and in the interpretation of research data. Selection of an antipsychotic drug should be on an individual patient basis. Patients should be involved in prescribing decisions and this should involve discussion about adverse drug reactions and their severity. Objective: Current study was carried out with the aim to look into the severity with which the adverse drug reactions were associated with various antipsychotics used in our day to day practice. Materials and Methods: It was a prospective observational study conducted over a period of one year in the Outpatient Department of Institute of Mental Health and Neurosciences (IMHNS), Government Medical College Srinagar. An assessment of severity was done using modified Hartwig and Siegel scale. Results: A total of 100 ADRs of different types were observed in 77 patients out of total 177 patients included in our study, with an overall prevalence of about 43.5\%. Most (83.0\%) of the ADRs were mild in severity while ADRs moderate in severity were found in only 17 (17.0\%) according to modified Hartwig and Siegel scale. None of the reported ADRs belonged to {\textquoteleft}severe{\textquoteright} or {\textquoteleft}lethal{\textquoteright} category. There was no statistically significant relationship between development of ADRs with age (p=0.8) or sex (p=0.6) of the patients included in the study. Conclusion: Although with the utilization of antipsychotics, the prevalence of ADRs in our study was as high 43.5\%, most of them (83\%) were mild in nature and only 17\% of them were of moderate severity and none of our patients showed the development of any severe ADR which would lead them to discontinue the therapy.

}, keywords = {ADR prevalence, ADR reporting, ADR severity due to Antipsychotics, Antipsychotics and ADRs, Modified Hartwig and Siegel scale}, doi = {10.5530/ijpcs.5.1.3}, author = {Afkat Ahmad and Arshad Hussain and Samina Farhat and Shagufta Parveen and Vineeta Sawhney and Zubair Ashai} } @article {173, title = {Knowledge, Attitude and Practice of Adverse Drug Reaction Reporting Among Doctors in a Tertiary Health Care Centre in South India}, journal = {International Journal of Pharmacology and Clinical Sciences}, volume = {2}, year = {2013}, month = {September 2013}, pages = {82-88}, type = {Research Article}, chapter = {82}, abstract = {

Background: A fundamental determinant to medical drug safety surveillance is voluntary adverse drug reaction [ADR] reporting ; but there exists substantial under-reporting which is the main drawback of the system. The objective of the study was to evaluate the knowledge, attitude and practice of ADR reporting among doctors in a tertiary health care center. Materials and Methods: A cross sectional questionnaire based study was conducted on doctors in a tertiary health care center. Participants were selected randomly and those not willing to participate were excluded from the study. Collected data was assessed by frequency, percentage, mean and standard deviation. Statistical analysis was performed by using SPSS version 13.0. Results: 75\% (45) of respondents were aware of the existence of ADR reporting system in India; on the contrary only (11.7\%) of respondents were aware of regional center for ADR reporting. All respondents (100\%) felt that seriousness of the ADR event, unusual reaction (95\%), reaction to new drug (98.33\%), and the certainty of ADR reaction (91.66\%) would encourage them to report an ADR event. However, only 15 out of 60 respondents (25\%) have reported ADRs. Conclusion: Though the level of knowledge about ADR reporting and the attitude towards ADR reporting were adequate, our study has shown that the actual practice of ADR reporting is unsatisfactory. This indicates that there is a need to create an awareness of the importance of ADR reporting through continuous medical education and training of ADR reporting among doctors.

}, keywords = {ADR reporting, Adverse drug reaction}, author = {Tanya Mary Thomas and Padmaja Udaykumar and Scandashree K} }